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I think a lot about the anime I watch and here I will tell you about some of the ideas I've developed. I will try to date this up as much as possible but don't keep your hopes up too much. Thos who know me from one or another forum might already have read some of the stuff in here. Trigun (meaning of the name)

"Trigun" the name itself could be best translated into "the third view'. The entire series is about how Vash and Knives look upon the world and how Vash’s view might be better but isn’t a philosophy upon which the foundation of a world can be built. The name itself is built up from two elements "Tri" and "Gun" I will lay them out for you in reversed order:

"GUN"
The word "Gun" is used to symbolise a view or take upon the world because man’s only natural weapon is his wits. All animals have some sort of way to defend themselves. Humanity however gave up all his defences in favour of his brain. Thus the way in which he uses his mind (the way he looks at the world) can be called his "Gun", or his "weapon".

"TRI"
The three views to which the first half of the name refers are the following:
1. The first view is the philosophy as followed by Rem Savarem. Vash takes up her point of view during his youth.
2. The second view is the philosophy as followed by Knives. He was much less easily influenced by Rem during his youth and even rebelled against her by taking up an exactly opposite take on life. Wolfwood and all the other Gung Ho Guns share Knives view but realise later on (while fighting with Vash) that they are not right at all.
3. The third view is the one that doesn’t exist and with which the story ends. Vash carries his brother into the world of man to show him that he was wrong about mankind at the end of the series. Vash himself does realise however that he’s been following a foolishly idealistic view that is impossible to make real. The two of them (being the oldest and most experienced people on the planet) will have to deliberate on a way in which humanity can live without destroying all that is around them.

The usual take on the name Trigun is that it refers to the three weapons that Vash uses throughout the series. First of all, Vash doesn’t have a total of three weapons but four. His gunarm gets replaced halfway through the series. Second of all, his silver gun and his angel arm are one and the same. Anyway at every moment he carries only two weapons and one of them is really not that important.

It would be madness if Wolfwood’s cross and the two .445 colts should be the three guns mentioned since in the tv series Chapel the Evergreen was added who carries another cross. Would they really insert a character that destroyed the symbolism of the name of the series?

Added thought (needs work probably):
The opening tune of the TV-series shows Vash’s and Knives’ guns crossing with one of the light-bulb-like-power-plants in the background. The beings within the power plants are humans who found the openness of mind to meld (live in harmony) with that which surrounds them. The scary thing however is that their world is a fragile one (which is shown when Hopperd the Gauntlet destroys one of the shells). They stand in direct contact with the energy of the world and embrace it to give it on to others, the ultimate self sacrifice. Sacrificing things yourself is one of the keys to obtaining a perfect world. If nobody thought about himself but only about sustaining others then we’d end up with a world devoid of hunger, disease, poverty and war.